| Oct 20 | Missouri State at Delaware | +1.0 | -3.0 | Base | Missouri State +3.0 | Missouri State |
| Oct 20 | Middle Tennessee at FIU | -8.0 | -10.0 | — | — | FIU |
| Oct 20 | South Alabama at Marshall | +11.0 | +3.0 | Base | South Alabama -3.0 | South Alabama |
| Oct 21 | New Mexico State at Sam Houston | +5.5 | +3.0 | — | — | New Mexico State |
| Oct 22 | James Madison at Appalachian State | +18.0 | +10.5 | Base | James Madison -10.5 | James Madison |
| Oct 22 | Liberty at Kennesaw State | +11.5 | +10.5 | — | — | Liberty |
| Oct 22 | East Carolina at Memphis | -13.5 | -10.5 | Base | Memphis -10.5 | Memphis |
| Oct 23 | NC State at Stanford | +6.5 | +7.0 | — | — | NC State |
| Oct 23 | Army at Tulsa | +12.0 | -1.5 | Lock | Army +1.5 | Army |
| Oct 23 | UMass at UConn | +1.5 | -14.5 | Century | UMass +14.5 | UMass |
| Oct 23 | Duke at Virginia | +7.5 | -1.5 | Base | Duke +1.5 | Duke |
| Oct 23 | Air Force at Wyoming | +12.0 | +4.5 | Base | Air Force -4.5 | Air Force |
| Oct 24 | Texas A&M at Alabama | -28.0 | -14.5 | Lock | Alabama -14.5 | Alabama |
| Oct 24 | Iowa State at Arizona | -6.5 | -10.0 | Base | Iowa State +10.0 | Arizona |
| Oct 24 | Kansas State at Arizona State | +11.0 | +3.5 | Base | Kansas State -3.5 | Kansas State |
| Oct 24 | Georgia State at Arkansas State | +11.0 | +2.5 | Base | Georgia State -2.5 | Georgia State |
| Oct 24 | LSU at Auburn | +9.5 | +7.5 | — | — | LSU |
| Oct 24 | Sacramento State at Ball State | -14.0 | -14.0 | — | — | Ball State |
| Oct 24 | Bowling Green at Buffalo | -14.0 | -3.5 | Lock | Buffalo -3.5 | Buffalo |
| Oct 24 | Miami (OH) at Central Michigan | +11.5 | +2.5 | Base | Miami (OH) -2.5 | Miami (OH) |
| Oct 24 | Texas Tech at Cincinnati | +29.0 | +10.5 | Century | Texas Tech -10.5 | Texas Tech |
| Oct 24 | Virginia Tech at Clemson | +0.5 | -2.5 | Base | Virginia Tech +2.5 | Virginia Tech |
| Oct 24 | San Diego State at Colorado State | +4.0 | +1.5 | — | — | San Diego State |
| Oct 24 | Rice at FAU | -13.5 | -8.5 | Base | FAU -8.5 | FAU |
| Oct 24 | Boston College at Georgia Tech | +9.5 | -4.0 | Lock | Boston College +4.0 | Boston College |
| Oct 24 | Oregon at Illinois | +32.5 | +8.5 | Millennium | Oregon -8.5 | Oregon |
| Oct 24 | Baylor at Kansas | +9.5 | +3.0 | Base | Baylor -3.0 | Baylor |
| Oct 24 | Akron at Kent State | -5.5 | -3.0 | — | — | Kent State |
| Oct 24 | Vanderbilt at Kentucky | -35.5 | -11.5 | Millennium | Kentucky -11.5 | Kentucky |
| Oct 24 | Old Dominion at Louisiana Tech | -15.0 | -12.5 | — | — | Louisiana Tech |
| Oct 24 | Pittsburgh at Miami | -26.5 | -20.5 | Base | Miami -20.5 | Miami |
| Oct 24 | Indiana at Michigan | +16.5 | +7.0 | Base | Indiana -7.0 | Indiana |
| Oct 24 | Iowa at Minnesota | +17.5 | +7.0 | Lock | Iowa -7.0 | Iowa |
| Oct 24 | Oklahoma at Mississippi State | -6.5 | +3.5 | Lock | Mississippi State +3.5 | Mississippi State |
| Oct 24 | North Texas at Navy | +13.0 | +1.5 | Lock | North Texas -1.5 | North Texas |
| Oct 24 | San Jose State at Nevada | +7.5 | -5.5 | Lock | San Jose State +5.5 | San Jose State |
| Oct 24 | North Dakota State at New Mexico | +3.0 | -4.5 | Base | North Dakota State +4.5 | North Dakota State |
| Oct 24 | Syracuse at North Carolina | -23.5 | -8.5 | Lock | North Carolina -8.5 | North Carolina |
| Oct 24 | Hawaii at Northern Illinois | +3.5 | +4.5 | — | — | Hawaii |
| Oct 24 | Rutgers at Northwestern | -22.0 | -16.5 | Base | Northwestern -16.5 | Northwestern |
| Oct 24 | Eastern Michigan at Ohio | -15.0 | -12.5 | — | — | Ohio |
| Oct 24 | Colorado at Oklahoma State | -21.0 | -13.5 | Base | Oklahoma State -13.5 | Oklahoma State |
| Oct 24 | California at SMU | -15.5 | -18.5 | Base | California +18.5 | SMU |
| Oct 24 | Tennessee at South Carolina | +17.5 | -2.5 | Millennium | Tennessee +2.5 | Tennessee |
| Oct 24 | Louisiana at Southern Miss | +16.0 | +10.0 | Base | Louisiana -10.0 | Louisiana |
| Oct 24 | West Virginia at TCU | +1.5 | -8.5 | Lock | West Virginia +8.5 | West Virginia |
| Oct 24 | Ole Miss at Texas | +19.5 | -3.5 | Millennium | Ole Miss +3.5 | Ole Miss |
| Oct 24 | Utah State at Texas State | +4.5 | -12.5 | Century | Utah State +12.5 | Utah State |
| Oct 24 | Western Michigan at Toledo | +6.5 | -3.0 | Base | Western Michigan +3.0 | Western Michigan |
| Oct 24 | UL Monroe at Troy | -12.5 | -15.5 | Base | UL Monroe +15.5 | Troy |
| Oct 24 | UTSA at Tulane | +6.5 | +2.5 | Base | UTSA -2.5 | UTSA |
| Oct 24 | BYU at UCF | +26.5 | +6.5 | Millennium | BYU -6.5 | BYU |
| Oct 24 | Michigan State at UCLA | -26.5 | -14.0 | Lock | UCLA -14.0 | UCLA |
| Oct 24 | Houston at Utah | -2.5 | -6.5 | Base | Houston +6.5 | Utah |
| Oct 24 | Boise State at Washington State | +18.0 | +13.5 | Base | Boise State -13.5 | Boise State |
| Oct 24 | USC at Wisconsin | +4.0 | +3.0 | — | — | USC |